Italian star Valentino Rossi finished 18th after tumbling off his bike on the 16th lap and losing the lead to newly-crowned world champion Marc Marquez, AFP reported.
Nine-time world champion Rossi, second on the grid, looked to be heading for his first win in Malaysia since 2010 as he dominated the early stages.
However Marquez, who qualified in pole position but was hit with a six-place grid penalty for impeding another rider, slowly worked his way through the pack.
Watch the moment Rossi tumbled off his Yamaha: