The FIA rejected the team's request that, because an unprecedented five weeks have passed since the BAR ban, engine changes be allowed without penalty.
Honda vice president Otmar Szafnauer told Autosport that the 2005 engine 'wasn't designed' to sit idle for weeks.
He said: "Metals corrode, seals deteriorate, and that is our concern. We just don't like to run something we have not thoroughly tested."
Szafnauer also denied that Honda, who undoubtedly have also developed the V10 since Imola, might decide to change Jenson Button and Takuma Sato's engine as a precaution.
"If something happens in qualifying," he added, "that might change."