You can argue the merits of V12s, V10s, V8s, V6s, and boxer engines all you like, but the most harmonised and perfect engine configuration is in the in-line six.
And it has nothing to do with numerology and everything to do with physics.
Powerful, with an inherent balance impossible to engineer into other engine configurations, in-line sixes are the choice for those drivers who value the perfect blend of smoothness and power.